abstract：:In response to a prolonged pressure- or volume-overload, alterations occur in myocardial fatty acid, glucose, and glycogen metabolism. Oxidation of long chain fatty acids has been found to be reduced in hypertrophied hearts compared to non-hypertrophied hearts. However, this observation depends upon the degree of card...

journal_title：Heart failure reviews

authors： Sambandam N,Lopaschuk GD,Brownsey RW,Allard MF

更新日期：2002-04-01 00:00:00

abstract：:It is now clear that diastolic heart failure (DHF) is an important, perhaps even dominant form of heart failure in older Americans. However, our knowledge base regarding the epidemiology, pathophysiology, natural history, and therapy of this relatively recently recognized disorder is limited. A number of normal age re...

journal_title：Heart failure reviews

authors： Kitzman DW

更新日期：2002-01-01 00:00:00

abstract：:Since its discovery in 1988, there has been increasing evidence that endothelin-1 (ET-1) plays an important role in the pathophysiology of hypertension and its related end-organ damages. First studies, using ET-1 administration in animals or in humans suspected this role by demonstrating the hypertensive properties of...

journal_title：Heart failure reviews

authors： Donckier JE

更新日期：2001-12-01 00:00:00

abstract：INTRODUCTION:Heart transplantation has become an acceptable treatment in pediatric patients with end-stage heart disease and complex congenital heart disease. The liberalization of recipient eligibility criteria, mainly age, along with the expansion of the donor pool has resulted in the acceptable transplantation of ol...

journal_title：Heart failure reviews

authors： Laks H,Marelli D,Odim J,Fazio D

更新日期：2001-09-01 00:00:00

abstract：:The prognosis for patients with congestive heart failure (CHF) has been improved as a result of the use of angiotensin converting enzyme inhibitors and beta-adrenergic receptor blockers. The success of these therapies underscores the pathogenic role of neurohormonal activation in CHF. Clinical and experimental evidenc...

journal_title：Heart failure reviews

authors： Kan H,Finkel MS

更新日期：2001-03-01 00:00:00

abstract：:In addition to functional alterations, heart failure has a structural basis as well. This concerns all components of the cardiac myocytes as well as the extracellular space. Proteins of the cardiomyocyte can be subdivided in 5 different categories: 1) Contractile proteins including myosin, actin, tropomyosin and the t...

journal_title：Heart failure reviews

authors： Kostin S,Hein S,Arnon E,Scholz D,Schaper J

更新日期：2000-10-01 00:00:00

abstract：:An important feature of heart failure is the progressive deterioration of left ventricular function that occurs in the absence of clinically apparent intercurrent adverse events. The mechanism or mechanisms responsible for this hemodynamic deterioration are not known. We and others have advanced the hypothesis that th...

journal_title：Heart failure reviews

authors： Sabbah HN,Sharov VG,Goldstein S

更新日期：2000-06-01 00:00:00